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Basic Principles of Drug Discovery and Development
Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields.Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator’s fields.This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist’s early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development.It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process.The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process.
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Web-Scale Discovery Services : Principles, Applications, Discovery Tools and Development Hypotheses
Web-Scale Discovery Services: Principles, Applications, Discovery Tools and Development Hypotheses summarizes and presents the state-of-the-art in WSDS.The title promotes a middle-way between finding the best tool for each particular need and the search for the most reliable systems.The title identifies basic theoretical problems and offers practical solutions for librarians.The volume offers a summary of ideas from around the world, giving a new perspective that is backed up by strong theory.Offering a vision for libraries, this book also allows archivists, museum specialists, computer scientists, commercial operators and interested users to deepen their culture and information literacy. The great number of information sources now available and the changing habits of web users has led to the development of Web Scale Discovery Services (WSDS).The goal of these systems and techniques is to make catalogues, databases, institutional repositories, Open Access archives and other databases searchable and discoverable through a single point of access.The diffusion of systems and connections between data disseminated by libraries and published by other institutions poses a challenge to understanding discovery in the modern library.
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Childhood and Nature : Design Principles for Educators
Childhood and Nature is a guide for educators looking to foster in their students a love of nature as well as an understanding of complex environmental issues.This second edition brings new material and fresh insights to David Sobel's foundational exploration of place-based education. Sobel articulates seven design principles that teachers can use to build learning experiences: adventure, fantasy and imagination, animal allies, maps and paths, special places, small worlds, and hunting and gathering,.Pulling from recurrent play themes and real-world examples from educators, Sobel details placed-based projects and lessons for each principle.Students learn and develop vital skills through engagement with their local environments and communities.Miniature ecosystems in the "small world" of a sandbox, for example, can help children grasp larger, abstract ideas.A timely and actionable resource, Childhood and Nature shows how centering the world around us in education can create a generation of nature students, explorers, and protectors.
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Paddington Sightseeing Adventure
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Nature as Teacher: New Principles in the Working of Nature
Nature as Teacher: New Principles in the Working of Nature
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Nature-Derived Sensors : Basic Principles and Recent Advances
Nature-Derived Sensors: Basic Principles and Recent Advances offers a wide range of information on nature-inspired solutions for modern sensor technology.A branch of biomimetics science, biomimetic sensors, and sensing technologies have grown rapidly and widely and therefore have found real industrial applications as emerging technologies.As a result of the demand for low-cost, high-quality, and smart sensors, challenges across many scientific fields can be resolved by learning from nature solutions. This book begins with an introductory section dealing with fundamental and basic information about biomimetic mechanisms, materials, algorithms, and tools.Various classes of nature-inspired sensors are also discussed.This book is an excellent reference for graduate students and researchers working with biomimetic sensors, their industrial applications, data science, artificial intelligence, and the Internet of Things in the processing of sensory data.
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Culture, Conduct and Ethics in Banking : Principles and Practice
Endorsed by the Chartered Banker Institute as core reading for its professional qualifications, Culture, Conduct and Ethics in Banking emphasizes the importance of professionalism for banks, and explores how all staff play a key role in putting customers at the heart of their business.Taking an applied approach, it aims to develop the reader's capability to: recognize and contribute towards balanced outcomes for consumers and organizations; understand the impact of reputational deficit; and understand the personal impact of an individual in the workplace. From a discussion of the main branches of ethical thinking to an overview of regulation and legislation in the UK and internationally, this book covers the theory and practice of conduct and professionalism in banking.Chapters contain activities and industry case studies, and further reading and viewing suggestions are included to help develop a deeper understanding of the topics covered.With fully referenced discussion of conflicts of interest, decision making models, the role of professional bodies, corporate governance, conduct risk management and the Global Financial Crisis 2007-08, Culture, Conduct and Ethics in Banking is the essential guide for finance professionals.
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Exploration and Discovery
The discovery and mapping of the world, its peoples, oceans and continents, are the result of centuries of exploration.This book traces the history of such travel and the pioneers who pushed back the frontiers of the known world.It explains the reasons for their journeys, whether out of scientific curiosity, to create trading opportunities, to spread religious beliefs or for personal gain or glory.With the aid of over 250 illustrations, maps and photographs, this accessible reference work captures all the excitement and spirit of adventure.
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