Products related to Target:
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Polypharmacology : Strategies for Multi-Target Drug Discovery
Practical guide to navigate problems involved with promiscuous ligands and multi-target drug discovery, supported by case studies and real examples Polypharmacology covers the two-sided nature of polypharmacology: its relevance for adverse drug effects, as well as its benefit for certain therapeutic drug classes in effectively treating complex diseases like psychosis and cancer.The book provides practical guidelines and advice to help readers design drugs that have multiple targets while minimizing unwanted off-target effects, discusses important disease areas like viral infection, diabetes, and obesity that have advanced significantly in the last decade, and guides researchers in neighboring areas to polypharmacology.The book is divided into four parts. Part A covers the link between off-targets and adverse drug reactions, how to screen for off-target activity, and how to recognize and optimize compounds with a potential for off-target activity.Part B discusses disease areas which benefit from polypharmacological approaches.Part C highlights important approaches, such as compound design, data mining with web-based tools, and multi-target peptides.Part D provides case study coverage on topics like CDK4/6 inhibitors for cancer treatment, the potential of multi-target ligands for COVID, and protein degraders and PROTACs.Sample topics discussed in Polypharmacology include: Molecular properties and structural motifs in pharmacological promiscuity, covering lipophilicity, molecular weight, and other parametersKinase liabilities in early drug discovery, covering core kinases driving the cell division cycle and consequences of interference, and cell cycle checkpoints controlling cell divisionTreatment of major depressive disorder, covering tricyclic antidepressants, monoamine oxidase inhibitors, and selective serotonin and norepinephrine reuptake inhibitorsTrends in the field, such as novel antipsychotics, standardization of screening tools, and the SmartCube System®, as well as lessons from history Delivering the latest research developments in the field, Polypharmacology is an essential reference on the subject for medicinal chemists, pharmacologists, biochemists, computational chemists, and biologists, as well as pharmaceutical professionals involved in drug discovery programs.
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Target Discovery and Validation : Methods and Strategies for Drug Discovery
The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation.With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods.Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research.This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume.It also includes numerous practical examples.
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Oxford Helmet Bumper Protector - Target, Target
The Oxford Helmet Bumper is part of the latest Oxford collection. Avoid rider and pillion helmets coming together with an uncomfortable 'thwack' by using the innovative new Oxford Bumper helmet protector! These knocks are almost unavoidable when riding pillion, but if you attach a Bumper to the back of the rider's helmet you can minimise the damage and discomfort. However, here's the really clever bit? This unique product uses a carefully formulated blend of special materials to be extremely grippy without using adhesives. This means that you can take it on and off any number of times - either for re-positioning purposes or because you only want to use it when riding with a pillion. Key Features / Points: Anti-Scratch Re-Usable No Glue Used Weather Resistant Universal View all Oxford Helmet Accessories . View all Helmet Accessories .
Price: 9.99 £ | Shipping*: 1.99 £ -
1Pcs Inflatable Entertainment Sticky Target Football Sticky Target Ball Football Shooting Target
1Pcs Inflatable Entertainment Sticky Target Football Sticky Target Ball Football Shooting Target
Price: 10.79 € | Shipping*: 5.13 €
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Which travel destination causes wanderlust when traveling alone?
Traveling alone to destinations like Bali, Indonesia, or the Amalfi Coast in Italy can cause wanderlust. These places offer stunning natural beauty, rich cultural experiences, and opportunities for self-discovery. The freedom to explore at your own pace and immerse yourself in the local culture can create a sense of wanderlust and adventure. Additionally, the chance to meet new people and make meaningful connections can add to the allure of these destinations for solo travelers.
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Which travel destination do you recommend for an adventure vacation in 2022?
I recommend Iceland as a travel destination for an adventure vacation in 2022. With its stunning landscapes including volcanoes, glaciers, hot springs, and waterfalls, Iceland offers a wide range of outdoor activities such as hiking, glacier trekking, snorkeling in crystal-clear waters, and exploring ice caves. Additionally, you can witness the mesmerizing Northern Lights during the winter months. Iceland's unique natural beauty and thrilling adventures make it a perfect choice for an unforgettable adventure vacation in 2022.
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Do tanks target automatically?
Tanks do not target automatically. They require human input to identify and engage targets. Tank operators use various sensors and targeting systems to locate and track potential threats, and then they manually aim and fire the tank's weapons. While some modern tanks may have advanced targeting and fire control systems, the decision to engage a target is ultimately made by the tank crew.
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What are eye and target?
In the context of marketing and advertising, "eye" refers to the attention or focus of a consumer or audience on a particular product, brand, or message. It represents the ability of a marketing campaign to capture and hold the attention of potential customers. On the other hand, "target" refers to the specific demographic or audience that a marketing campaign is aiming to reach and influence. This could include factors such as age, gender, income level, geographic location, and interests. Both "eye" and "target" are important concepts in developing effective marketing strategies and campaigns.
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1Pcs Inflatable Entertainment Sticky Target Football Sticky Target Ball Football Shooting Target
1Pcs Inflatable Entertainment Sticky Target Football Sticky Target Ball Football Shooting Target
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The Target
The Target is David Baldacci's blockbuster follow up to The Hit, the smash-hit bestseller featuring U.S. government assassin, Will Robie. A highly trained CIA assassin, Will Robie is only matched in his ability to kill by his fellow agent, Jessica Reel.They are trusted by the US government to succeed when failure isn’t an option. So when the President identifies an opportunity to take down a global menace there’s only two people he has in mind for the clandestine mission.Their target is the dangerous and unpredictable leader of North Korea, but when things don’t go to plan a fierce retaliation is set in motion. While Robie and Reel are stalked by a new adversary – sent to destroy the enemy at all costs – a deadly game of cat and mouse is triggered between the East and West.But who will be hunter and who will be hunted when the true target is revealed?Continue the thrilling series with The Guilty.
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Target: Terror
The Scope of JusticeWithin a military that prides teamwork, strength in numbers, and camaraderie, the sniper is the outlier.The loner. The specialist whose talent can mean the difference between mission success and disaster. And often between life and death.Kyle Monroe is one of this exclusive fraternity.Recovering from a mission gone disastrously wrong, Monroe is paired with new partner Wade Curtis and dispatched to Pakistan, where he’s been instructed to take out a prominent member of al Qaeda.But the local tribe to which he’s assigned wants to use his deadly skills to settle a private war with a neighboring tribe.If Monroe and his partner want to get out of Pakistan alive, they will have to rely on their skills, their experience—and the unrelenting drive of those who are called to be the best of the best in a lethal occupation.Targets of OpportunityMaster snipers Kyle Monroe and Wade Curtis got more than they bargained for on assignment to Pakistan to take out a powerful terrorist chieftain.Now they find themselves in Romania, in a densely packed urban environment, and in hidden tunnels beneath a legendary castle.Here they stalk a terror cell that is smuggling explosives across the Black Sea into Europe.Romania may have a legacy of horror, but Vlad the Impaler has nothing on these terrorist murderers.Fortunately, there are a couple of expert shooters on the side of the angels, and their names are Monroe and Curtis!Confirmed KillArmy Rangers Kyle Monroe and Wade Curtis are the best at what they do: eliminating their nation’s enemies from a distance with one well-placed bullet to the head.When intelligence catches wind of a terrorist plot unfolding in the jungles of Indonesia, Monroe and Curtis are the snipers assigned to take the killers out.Failure is not an option, since al Qaeda-linked fanatics plan to blow an oil-rich province sky high, taking hundreds of innocent lives, many of them American.But the military brass is saddling their operatives with unnecessary and potentially lethal baggage—an overweight, under-trained colonel whose ineptitude could prove disastrous. And when their mission goes all to hell, two crack snipers are suddenly transformed into targets caught out in the open—facing an army of terrorist murderers pouring out of the trees and with nowhere to run.About Michael Z.Williamson:“A fast-paced, compulsive read . . . will appeal to fans of John Ringo, David Drake, Lois McMaster Bujold, and David Weber.”—Kliatt“Williamson's military expertise is impressive.”—SFReviews
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Shadow Target
Price: 24.99 £ | Shipping*: 3.99 £
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What is a math target?
A math target is a specific skill or concept that a student is working towards mastering in mathematics. It is a goal that helps guide the student's learning and progress in a particular area of math. Math targets can be set by teachers to help students focus on specific areas of improvement and track their progress towards achieving mastery. By setting clear math targets, students can work towards improving their understanding and proficiency in math.
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What is a target image?
A target image is a reference image or a desired outcome that a person or a system aims to achieve or replicate. It serves as a benchmark or a goal to work towards. In various fields such as computer vision, machine learning, and image processing, a target image is used as a comparison point for evaluating the performance of algorithms or models. By comparing the output of a system to the target image, one can assess the accuracy and effectiveness of the process.
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How can one target Porsche?
One can target Porsche by conducting market research to understand the brand's target audience and their preferences. Developing a marketing strategy that highlights Porsche's unique selling points, such as luxury, performance, and craftsmanship, can help attract potential customers. Utilizing digital marketing channels, such as social media and online advertising, can also help reach a wider audience interested in luxury cars like Porsche. Additionally, collaborating with influencers or partnering with luxury brands can help increase brand visibility and appeal to a more affluent demographic.
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What are target text formats?
Target text formats refer to the specific types of documents or files that a text may need to be converted into or formatted as. This could include formats such as PDF, Word document, HTML, or plain text. Target text formats are important to consider when translating or localizing content to ensure that the text is presented in the appropriate format for its intended use or audience.
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